Hepadetox

Description

Each 1 gm contains:

Amla 30mg, Harde 20mg, Baheda 20mg, Bhumi Amalaki 20mg, Punarnava 80mg, Harsingar Leaf 20mg, Puskarmool 20mg, Bhangra 60mg, Suddha Shilajeet 50gm, Suddha Guggul 50mg, Kutaki 400mg, Yastimadhu 50mg, Guduchi 60mg, Chireta 60mg, Haridra 60mg, Neem Leaf 30mg,

Mechanism Of Action

• The liver plays an astonishing array of vital functions in the maintenance, performance and regulating homeostasis of the body.
• It is involved with almost all the biochemical pathways to growth, fight against disease, nutrient supply, energy provision and reproduction.
• And it functions as a centre of metabolism of nutrients such as carbohydrates, proteins and lipids and excretion of waste metabolites.
• The bile secreted by the liver has, among other things, plays an important role in digestion. Therefore, maintenance of a healthy liver is essential for the overall well being of an individual
• Liver is a vital organ playing a major role in metabolism and excretion of xenobiotics from the body.
• Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies.
• Liver cell injury caused by various toxic chemicals (certain anti-biotic, chemotherapeutic agents, carbon tetrachloride (CCL4), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied.

Hepa Detox: Pharmacological evaluation
Efficacy studies: Assessment of liver function & Histopathology

• Biochemical parameters i.e., aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), γ-glutamate transpeptidase (GGTP), total bilirubin and total protein, were analyzed according to the reported methods. The liver was removed, morphological changes were observed.
• A 10% of liver homogenate was used for antioxidant studies such as lipid peroxidation (LPO), superoxide dismutase (SOD), Catalase, glutathione peroxidase (GPx), and glutathione S-transferase (GST).
• A portion of liver was fixed in 10% formalin for histopathological studies.
• After draining the blood, liver samples were excised, washed with normal saline and processed separately for histopathological observation. Initially the materials were fixed in 10% buffered neutral formalin for 48 hour and then with bovine solution for 6 hour. Paraffin sections were taken at 5 mm thickness processed in alcohol-xylene series and was stained with alum hematoxylin and eosin. The sections were examined microscopically for histopathology changes.
• Statistical analysis
• The values were expressed as mean ± SEM. Statistical analysis was performed by one way analysis of variance (ANOVA) followed by Tukey multiple comparison tests. P values < 0.05 were considered as significant.